Mercedes Benz E350 owners have reported 1 problem related to brake disc caliper (under the service brakes category).
2007 e-350 Mercedes Benz sedan 40,000 miles; had two brake failures: popping sound from brakes as if calipers stuck and released; brake pedal goes to floor. Little if any braking power; brakes generate excessive heat but then recover to normal. On both incidences (8/31 and 8/21) mechanic could not replicate despite multiple test drives (in shop 5 days) car now again garaged. Afraid to drive. Mb not responsive.
See all problems of the 2007 Mercedes Benz E350.