One problem related to door latch has been reported for the 2001 Acura MDX. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2001 Acura MDX based on all problems reported for the 2001 MDX.
A damage to the driver-side door lock renders the whole locking (and unlocking) mechanism unusable. My driver-side door handle got scraped in locked position, while the car was being driven. Due to the damage to the driver side lock, it could not be operated electrically or manually. On parking the car I managed to get out the passenger side door but on closing the same door, the electrical system locked the door automatically. Since none of the other doors, including the one on the trunk, has a mechanical lock, the car cannot now be unlocked. There is now no way of getting into the car, without which the damaged door cannot be repaired. Acura motors did not have a way out of the situation.