One problem related to engine cooling system has been reported for the 2004 Acura MDX. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2004 Acura MDX based on all problems reported for the 2004 MDX.
Sudden transmission failure on the highway. Lose all power from the engine to the wheels. Has to pull over suddenly in traffic to avoid being hit by other cars traveling at normal speed. The transmissions on Honda/Acura v6s apparently have systematic problems.