One problem related to axle assembly has been reported for the 2005 Chevrolet Express 2500. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2005 Chevrolet Express 2500 based on all problems reported for the 2005 Express 2500.
The left front wheel bearing came apart with only 45,000 miles on the vehicle. I was on I-40 in a 70 mph zone I was very lucky that the van did not roll over.