One problem related to wheel bolts has been reported for the 2000 Ford E-150. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2000 Ford E-150 based on all problems reported for the 2000 E-150.
Driving 40 mph felt a slight shimmy thought I was getting a flat, started to pull to the shoulder, and before I was stopped the rear tire was already off, and upon my inspection all 5 lugs: nuts were sheared off. I walked back approx. 100 feet and found two. They were sheared in equal lengths.