One problem related to noises during shifting has been reported for the 2000 Ford E-250. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2000 Ford E-250 based on all problems reported for the 2000 E-250.
This vehicle has a "dead" spot between park and reverse giving one the impresion that the car is in park when in fact it is between park and reverse. It falls into this position rather easily. When the spring on the shifter itself is released it snaps mimiking the sound of the shifter engaging fully in park. The car will now be in a neutral postion where as the motor can be reved as if one was in park . Needless to say the car sliped into reverse after I had exited the vehicle causing an accident. In my opinion the shifter should not be able to get in this position as easily as it does and an "idiot" noise should sound if the door is openend letting one know the car is not engaged in park properly. This almost caused a catostophic accident.