One problem related to automatic transmission has been reported for the 2001 Ford E-250. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2001 Ford E-250 based on all problems reported for the 2001 E-250.
Bought vehicle in Jan 2001, 2003 started having transmission problems, slipping, not going in reverse, etc. Brought to jiffy lube, flushed out, seemed to work better. Now June 2004, same problem. I am lead to believe this is not an isolated case.