One problem related to fuel injector has been reported for the 2005 Ford E-250. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2005 Ford E-250 based on all problems reported for the 2005 E-250.
Normal driving of a 2005 Ford e 250 econoline van and smelled gas. When home, removed engine cover and discovered fuel line leak and significant pooling of gas on rear section of top of engine, the flex portion of the fuel line that feeds the fuel injection manifold had failed just before the connection to the injector. Upon removal of the fuel line (Ford part # 5c2z*9b325) it appears that the lower end of this upper flex line is also failing. I am replacing it with a new one from Ford, but I am concerned with the potential for a major fire if this is a design problem (wrong or inadequate material of construction.