One problem related to manifold/header/muffler/tail pipe has been reported for the 1997 Ford E-350. The most recently reported issues are listed below.
Oil filter housing unit bolted to left side of triton v-10 engine fell off the engine after bolts which held the housing apparently vibrated loose. The failure resulted destruction of both the sending and return oil lines to the oil cooler and also heavy damage to oil cooler after it too also fell after being yanked by the falling oil filter mounting unit. At time of failure there was no indication that there was an oil pressure problem because the instrument gages were still reading full pressure. Engine was saved from damage after driver shut engine off and steered motor home down a two lane road to where it could safely pull off. Note there is an extream fire hazard issue with this large amounts of oil sprayed on the left side engine manifold. Tires. Six firestone steeltex tires and a non-firestone spare tire were replaced due to sever cracking and evidence that tires were showing immenant failure. Tires were only load range d. Vehicle should have load range e. Replaced with non-firestones on all positions. (dot number: vd1l1xe127 tiresize: lt22575r16).