Two problems related to steering have been reported for the 1999 Ford E-350. The most recently reported issues are listed below.
I recently purchased a used 24� 1999 winnebago itasca spirit with very low mileage and at that time I noticed a shaking or vibration problem possibly coming from the tires. I owned a motor home in the past and have some experience. This motor home sat for several years so I attributed the shaking to the memory in the rubber of flat spots on the bottom from sitting for a long time that usually smooth out when driven especially after 30 or 40 miles on a warm day, but after a 400 mile trip it didn't smooth out, in fact it seems to have worsened. Before purchasing it from a private party I ran an instavin and carfax report and only discovered an uncompleted NHTSA recall #05s28 on the speed control only. I then searched several forums and discovered many, many reports of the same problem with the shaking and learned it is due to faulty wheels and Ford is not making good the problem but offered an expensive fix that I understand is also iffy. I am very concerned about my family's safety driving on these defective wheels and first looked into replacing the tires which I learned isn't the problem but the faulty wheels that were an oem Ford part, so I want to add my complaint to the many you already have and maybe Ford will fix this potentially serious safety problem.
While driving consumer hit a bump and steering became uncontrolable. Steering wheel almost jerked from driver's hands. A steering stabilizer was added to make vehicle driveable and it still is not normal.