One problem related to gasoline engine has been reported for the 2000 Ford E-350. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2000 Ford E-350 based on all problems reported for the 2000 E-350.
2000-Ford E-350 spark plug blew right out of the aluminum head.
| Engine And Engine Cooling problems | |
| Engine problems | |
| Gasoline Engine problems |