One problem related to tank filler pipe and cap has been reported for the 2001 Ford E-350. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2001 Ford E-350 based on all problems reported for the 2001 E-350.
While driving vehicle started running rough/missing lost engine power. Had to have the vehicle towed home replaced the fuel filter and pump. Still had problems. Towed to the dealer who finally advised fuel tank laminate was flaking. Found 4 other complaints on this site for the same problem. Online found that this is happening in multiple years/diesel types from Ford.