Two problems related to transmission slip out of gear have been reported for the 2004 Ford E-350. The most recently reported issues are listed below.
Automatic transmission will slip out of gear without warning during on-road operation.
5 speed automatic transmission occasionally jumps out of drive during normal operation of vehicle, engine revs for a second or two, then transmission slams back into drive.
| Transmission Slip Out Of Gear problems | |
| Power Train Driveline problems |