One problem related to engine cooling system has been reported for the 2005 Ford E-350. The most recently reported issues are listed below.
2005 Ford E-350 ambulance had a total ac system failure the Ford dealership service center diagnosed the cause and replaced it under warranty. This is compliant #3 of 6. All of the 2005 Ford ambulances we purchased have suffered major system failures from either the oil pumps or the wiring harness systems, and several have had ac problems as well. Ford is unwilling to replace these parts on the other units until they fail. They are placing numerous lives in extreme jeopardy and refuse to admit there are major problems with the 6. 0 l diesel engine in the 2005 series ambulance chassis.