One problem related to door latch has been reported for the 2006 Ford E-350. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2006 Ford E-350 based on all problems reported for the 2006 E-350.
Upon receipt of the vehicle from my van pool office it was noticed that the steering was stiff and did not self center after making lane changes. The steering will continue to go in the direction of the lane you moved into. It also has a constant pull to the left when going straight. In 7/06 it was noticed that the side doors made a loud popping sound once each way we drove to/from work. After about two weeks I determined that it was the top latch becoming disengaged. When this happens the door rattles.