One problem related to rear axle spindle has been reported for the 2000 Ford F-150. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2000 Ford F-150 based on all problems reported for the 2000 F-150.
Was on a slick road. I was going 15 miles an hour, when my 2000 Ford F-150 spun completely around. When the truck spun around it went towards the ditch backwards. When I hit the ditch the truck flipped onto the passenger side. When the tow truck arrived on the scene he informed me that the rear tire broke off the axle. I had never heard of this happening at such a slow speed, neither had the tow truck driver, especially since it was a heavy half ton load axle . When we were looking at the axle in the light it appeared that it crystallized and snapped. I am a welder and work with metal every day and the axle look almost like cast.