One problem related to frame rust has been reported for the 2001 Ford F-150. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2001 Ford F-150 based on all problems reported for the 2001 F-150.
Gas tank fell out of vehicle,tearing filler hose. Tank straps and supporting structures rust thru, failure. Drivers' side rear shock dropped from vehicle because metal bracket it was attached to rotted thru. Bed rails completely rusted thru. Frame has rusted thru holes. Complete rust failure. Vehicle has only 90k miles always maintained, washed underneath weekly in winter. Vehicle in motion when parts fell on rte 58 and the shock on town street. . $900 to repair gas tank. Shock incident happened today 11/26/2017, gas tank 9/12/2016.