One problem related to fuel injector has been reported for the 2006 Ford F-450. The most recently reported issues are listed below.
The contact owns a 2006 Ford 450. He stated that the fuel tank had delaminated, causing shards of the tank to break off into the fuel line. The vehicle was diagnosed by a local dealer who confirmed repairs would need to be made to the fuel tank, at the owners expense. The contact was concerned with the defective fuel tank affecting the fuel injectors and the motor. Repairs were made to the vehicle by the owner and an independent mechanic. The approximate failure mileage was 135,000 and the current mileage was 135,000.