One problem related to engine failure has been reported for the 2008 Ford F-450. The most recently reported issues are listed below.
Have had acceleration issues with this Ford F-450 since April of 2010, the first time the driver was able to stop the vehicle without incident but the engine blew up when he put it in neutral to stop the vehicle. It was at the Ford dealership for 6 weeks, I retrieved the vehicle, while on the way home the engine failed again, it was towed back to the dealership. 1 week later I retrieved the vehicle again, 2 days after that the accelerator stuck once again while hauling a trailer loaded with a rental trencher. This time the result was a traffic accident that sent one of my employees to the hospital and caused major property damage, the vehicle was towed back to the dealership and has been there ever since. They have replaced the short block, injectors, and other various engine components.