One problem related to fuel injector has been reported for the 2008 Ford F-450. The most recently reported issues are listed below.
This truck started having issue at 24,593 miles from the radiator, cooler, and gasket issues, replaced parts. Then 6 months later issue again on radiator and replace again. 4 days later back again for same issues. 1 month later again in shop for coolant leaking. Feb 2010 we replaced fuel pump assembly. July 2010 had to replace fuel system on vehicle and all 8 injectors. Had work done at another shop because 2 Ford dealerships where behind 2 weeks. Vehicle only had 39,849 mileage and Ford would not reimburse me since Ford dealer did not fix. October 2010 fuel sensors not work and had to pay for repair. Have 5 F-450 and all have issues.