One problem related to driveshaft has been reported for the 2019 Ford F-450. The most recently reported issues are listed below.
Wire harness for transmission was not secured properly,came loose and wrapped around deiveshaft ripping it off,and caused an coolant line to also pull off vehicle was running fine,70mph on freeway. . . Made a loud pop noise and transmission was grinding bad. . . Pulled over and shut it off immediately,lots of antifreeze under trick and wire harness ripped off and wrapped around front driveshaft(6-8ft of the wire harness).