One problem related to tailgate latch has been reported for the 2021 Ford F-450. The most recently reported issues are listed below.
While towing my gooseneck horse trailer the tailgate opened randomly. I had towed for about 20 miles and got off the freeway and was driving through a parking lot when it happened. When I turned the tailgate struck the horse trailer causing body parts to fall in the roadway which could be dangerous to other motorist. Normally when the tailgate is open a message appears on the dash. No message was received, no buttons on keys or dash were depressed to cause this to occur.