Fuel Economy of Mercedes-Benz CLS450 Cars

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The following table compares the fuel economies of different models of Mercedes-Benz CLS450 cars, across model years.
The annual fuel costs (shown in the right-hand columns) are calculated based on an estimated annual mileage of 15,000 miles, of which 55% of the miles are city driving, and 45% of the miles are highway driving. Annual Cost 1 assumes a fuel cost of $5.00 per gallon, while Annual Cost 2 assumes a fuel cost of $6.00 per gallon.

Table 1. Fuel Economy of Mercedes-Benz CLS450

Model YearTransmissionCyl. Combined
MPG
City
MPG
Highway
MPG
Annual
Cost 1
Annual
Cost 2
2021 CLS450Automatic 9-speed6 262330$2,918$3,502
2020 CLS450Automatic 9-speed6 262431$2,807$3,368
2019 CLS450Automatic 9-speed6 262431$2,807$3,368

Table 2. Fuel Economy of Mercedes-Benz CLS450 4matic

Model YearTransmissionCyl. Combined
MPG
City
MPG
Highway
MPG
Annual
Cost 1
Annual
Cost 2
2023 CLS450 4maticAutomatic 9-speed6 252230$3,000$3,600
2022 CLS450 4maticAutomatic 9-speed6 252230$3,000$3,600
2021 CLS450 4maticAutomatic 9-speed6 252229$3,038$3,646
2020 CLS450 4maticAutomatic 9-speed6 262330$2,918$3,502
2019 CLS450 4maticAutomatic 9-speed6 262330$2,918$3,502