
The following table compares the fuel economies of different models of Mercedes-Benz E350 cars, across model years.
The annual fuel costs (shown in the right-hand columns) are calculated based on an estimated annual mileage of 15,000 miles,
of which 55% of the miles are city driving, and 45% of the miles are highway driving.
Annual Cost 1 assumes a fuel cost of $5.00 per gallon, while Annual Cost 2 assumes a fuel cost of $6.00 per gallon.
| Model Year | Transmission | Cyl. | Combined MPG | City MPG |
Highway MPG |
Annual Cost 1 |
Annual Cost 2 |
|---|---|---|---|---|---|---|---|
| 2023 E350 4matic | Automatic 9-speed | 4 | 24 | 21 | 30 | $3,089 | $3,707 |
| 2022 E350 4matic | Automatic 9-speed | 4 | 24 | 21 | 29 | $3,128 | $3,753 |
| 2021 E350 4matic | Automatic 9-speed | 4 | 25 | 22 | 30 | $3,000 | $3,600 |
| 2020 E350 4matic | Automatic 9-speed | 4 | 25 | 22 | 30 | $3,000 | $3,600 |
| 2016 E350 4matic | Automatic 7-speed | 6 | 23 | 20 | 28 | $3,267 | $3,921 |
| 2016 E350 4matic | Automatic 7-speed | 6 | 23 | 20 | 28 | $3,267 | $3,921 |
| 2015 E350 4matic | Automatic 7-speed | 6 | 23 | 20 | 27 | $3,312 | $3,975 |
| 2015 E350 4matic | Automatic 7-speed | 6 | 23 | 20 | 27 | $3,312 | $3,975 |
| 2014 E350 4matic | Automatic 7-speed | 6 | 22 | 20 | 27 | $3,312 | $3,975 |
| 2014 E350 4matic | Automatic 7-speed | 6 | 23 | 20 | 28 | $3,267 | $3,921 |
| 2014 E350 4matic | Automatic 7-speed | 6 | 23 | 20 | 27 | $3,312 | $3,975 |
| 2013 E350 4matic | Automatic 7-speed | 6 | 22 | 19 | 28 | $3,376 | $4,051 |
| 2013 E350 4matic | Automatic 7-speed | 6 | 22 | 19 | 28 | $3,376 | $4,051 |
| 2013 E350 4Matic | Automatic 7-speed | 6 | 22 | 19 | 28 | $3,376 | $4,051 |
| 2012 E350 4matic | Automatic 7-speed | 6 | 22 | 19 | 28 | $3,376 | $4,051 |
| 2011 E350 4matic | Automatic 7-speed | 6 | 19 | 17 | 24 | $3,832 | $4,599 |
| 2010 E350 4matic | Automatic 7-speed | 6 | 19 | 17 | 24 | $3,832 | $4,599 |
| 2009 E350 4matic | Automatic 5-speed | 6 | 18 | 16 | 22 | $4,112 | $4,934 |
| 2008 E350 4matic | Automatic 5-speed | 6 | 18 | 16 | 22 | $4,112 | $4,934 |
| 2007 E350 4matic | Automatic 5-speed | 6 | 19 | 16 | 23 | $4,045 | $4,854 |
| 2006 E350 4matic | Automatic 5-speed | 6 | 19 | 16 | 23 | $4,045 | $4,854 |
| Model Year | Transmission | Cyl. | Combined MPG | City MPG |
Highway MPG |
Annual Cost 1 |
Annual Cost 2 |
|---|---|---|---|---|---|---|---|
| 2015 E350 Coupe | Automatic 7-speed | 6 | 22 | 19 | 28 | $3,376 | $4,051 |
| 2014 E350 Coupe | Automatic 7-speed | 6 | 23 | 20 | 28 | $3,267 | $3,921 |
| 2014 E350 Coupe | Automatic 7-speed | 6 | 23 | 20 | 28 | $3,267 | $3,921 |
| 2014 E350 Coupe | Automatic 7-speed | 6 | 24 | 20 | 30 | $3,187 | $3,825 |
| 2013 E350 Coupe | Automatic 7-speed | 6 | 23 | 19 | 29 | $3,334 | $4,001 |
| 2013 E350 Coupe | Automatic 7-speed | 6 | 23 | 20 | 28 | $3,267 | $3,921 |
| 2013 E350 Coupe | Automatic 7-speed | 6 | 23 | 20 | 28 | $3,267 | $3,921 |
| 2012 E350 Coupe | Automatic 7-speed | 6 | 22 | 19 | 28 | $3,376 | $4,051 |
| 2012 E350 Coupe | Automatic 7-speed | 6 | 23 | 20 | 28 | $3,267 | $3,921 |
| 2011 E350 Coupe | Automatic 7-speed | 6 | 20 | 17 | 26 | $3,724 | $4,469 |
| 2010 E350 Coupe | Automatic 7-speed | 6 | 20 | 17 | 26 | $3,724 | $4,469 |
| Model Year | Transmission | Cyl. | Combined MPG | City MPG |
Highway MPG |
Annual Cost 1 |
Annual Cost 2 |
|---|---|---|---|---|---|---|---|
| 2006 E350 (wagon) | Automatic 7-speed | 6 | 19 | 16 | 24 | $3,984 | $4,781 |
| Model Year | Transmission | Cyl. | Combined MPG | City MPG |
Highway MPG |
Annual Cost 1 |
Annual Cost 2 |
|---|---|---|---|---|---|---|---|
| 2014 E350 4matic Coupe | Automatic 7-speed | 6 | 23 | 20 | 28 | $3,267 | $3,921 |
| 2014 E350 4matic Coupe | Automatic 7-speed | 6 | 23 | 20 | 28 | $3,267 | $3,921 |
| 2014 E350 4matic Coupe | Automatic 7-speed | 6 | 23 | 20 | 28 | $3,267 | $3,921 |
| 2013 E350 4matic Coupe | Automatic 7-speed | 6 | 22 | 19 | 29 | $3,334 | $4,001 |
| 2013 E350 4matic Coupe | Automatic 7-speed | 6 | 22 | 19 | 27 | $3,421 | $4,105 |
| 2013 E350 4matic Coupe | Automatic 7-speed | 6 | 22 | 19 | 27 | $3,421 | $4,105 |
| 2012 E350 4matic Coupe | Automatic 7-speed | 6 | 22 | 19 | 27 | $3,421 | $4,105 |
| 2012 E350 4matic Coupe | Automatic 7-speed | 6 | 22 | 19 | 27 | $3,421 | $4,105 |
| Model Year | Transmission | Cyl. | Combined MPG | City MPG |
Highway MPG |
Annual Cost 1 |
Annual Cost 2 |
|---|---|---|---|---|---|---|---|
| 2013 E350 Bluetec | Automatic 7-speed | 6 | 25 | 21 | 32 | $3,018 | $3,622 |
| 2012 E350 Bluetec | Automatic 7-speed | 6 | 25 | 21 | 32 | $3,018 | $3,622 |
| 2011 E350 Bluetec | Automatic 7-speed | 6 | 26 | 22 | 33 | $2,897 | $3,477 |
| Model Year | Transmission | Cyl. | Combined MPG | City MPG |
Highway MPG |
Annual Cost 1 |
Annual Cost 2 |
|---|---|---|---|---|---|---|---|
| 2016 E350 4matic (wagon) | Automatic 7-speed | 6 | 22 | 20 | 27 | $3,312 | $3,975 |
| 2015 E350 4matic (wagon) | Automatic 7-speed | 6 | 22 | 20 | 26 | $3,360 | $4,032 |
| 2014 E350 4matic (wagon) | Automatic 7-speed | 6 | 22 | 20 | 26 | $3,360 | $4,032 |
| 2013 E350 4matic (wagon) | Automatic 7-speed | 6 | 22 | 19 | 27 | $3,421 | $4,105 |
| 2012 E350 4matic (wagon) | Automatic 7-speed | 6 | 22 | 19 | 27 | $3,421 | $4,105 |
| 2011 E350 4matic (wagon) | Automatic 7-speed | 6 | 19 | 16 | 23 | $4,045 | $4,854 |
| 2009 E350 4matic (wagon) | Automatic 5-speed | 6 | 18 | 16 | 21 | $4,185 | $5,022 |
| 2008 E350 4matic (wagon) | Automatic 5-speed | 6 | 18 | 16 | 21 | $4,185 | $5,022 |
| 2007 E350 4matic (wagon) | Automatic 5-speed | 6 | 18 | 16 | 22 | $4,112 | $4,934 |
| 2006 E350 4matic (wagon) | Automatic 5-speed | 6 | 18 | 16 | 22 | $4,112 | $4,934 |
| Model Year | Transmission | Cyl. | Combined MPG | City MPG |
Highway MPG |
Annual Cost 1 |
Annual Cost 2 |
|---|---|---|---|---|---|---|---|
| 2023 E350 | Automatic 9-speed | 4 | 26 | 23 | 31 | $2,882 | $3,458 |
| 2022 E350 | Automatic 9-speed | 4 | 26 | 23 | 31 | $2,882 | $3,458 |
| 2021 E350 | Automatic 9-speed | 4 | 25 | 22 | 31 | $2,963 | $3,556 |
| 2020 E350 | Automatic 9-speed | 4 | 26 | 23 | 32 | $2,848 | $3,417 |
| 2016 E350 | Automatic 7-speed | 6 | 23 | 20 | 29 | $3,226 | $3,871 |
| 2016 E350 | Automatic 7-speed | 6 | 23 | 20 | 29 | $3,226 | $3,871 |
| 2015 E350 | Automatic 7-speed | 6 | 23 | 20 | 28 | $3,267 | $3,921 |
| 2015 E350 | Automatic 7-speed | 6 | 23 | 20 | 28 | $3,267 | $3,921 |
| 2014 E350 | Automatic 7-speed | 6 | 24 | 20 | 30 | $3,187 | $3,825 |
| 2014 E350 | Automatic 7-speed | 6 | 23 | 20 | 29 | $3,226 | $3,871 |
| 2014 E350 | Automatic 7-speed | 6 | 23 | 20 | 28 | $3,267 | $3,921 |
| 2013 E350 | Automatic 7-speed | 6 | 23 | 19 | 29 | $3,334 | $4,001 |
| 2013 E350 | Automatic 7-speed | 6 | 23 | 20 | 29 | $3,226 | $3,871 |
| 2013 E350 | Automatic 7-speed | 6 | 23 | 20 | 29 | $3,226 | $3,871 |
| 2012 E350 | Automatic 7-speed | 6 | 23 | 20 | 30 | $3,187 | $3,825 |
| 2011 E350 | Automatic 7-speed | 6 | 20 | 17 | 25 | $3,776 | $4,531 |
| 2010 E350 | Automatic 7-speed | 6 | 21 | 18 | 26 | $3,589 | $4,307 |
| 2009 E350 | Automatic 7-speed | 6 | 19 | 17 | 24 | $3,832 | $4,599 |
| 2008 E350 | Automatic 7-speed | 6 | 19 | 17 | 24 | $3,832 | $4,599 |
| 2007 E350 | Automatic 7-speed | 6 | 19 | 17 | 24 | $3,832 | $4,599 |
| 2006 E350 | Automatic 7-speed | 6 | 20 | 17 | 25 | $3,776 | $4,531 |
| Model Year | Transmission | Cyl. | Combined MPG | City MPG |
Highway MPG |
Annual Cost 1 |
Annual Cost 2 |
|---|---|---|---|---|---|---|---|
| 2015 E350 Convertible | Automatic 7-speed | 6 | 23 | 20 | 28 | $3,267 | $3,921 |
| 2014 E350 Convertible | Automatic 7-speed | 6 | 23 | 20 | 28 | $3,267 | $3,921 |
| 2014 E350 Convertible | Automatic 7-speed | 6 | 22 | 19 | 28 | $3,376 | $4,051 |
| 2013 E350 Convertible | Automatic 7-speed | 6 | 22 | 19 | 28 | $3,376 | $4,051 |
| 2013 E350 Convertible | Automatic 7-speed | 6 | 22 | 19 | 28 | $3,376 | $4,051 |
| 2012 E350 Convertible | Automatic 7-speed | 6 | 22 | 19 | 28 | $3,376 | $4,051 |
| 2012 E350 Convertible | Automatic 7-speed | 6 | 22 | 19 | 28 | $3,376 | $4,051 |
| 2011 E350 Convertible | Automatic 7-speed | 6 | 20 | 17 | 25 | $3,776 | $4,531 |
Data source: Fuel Economy USA, Reference.