One problem related to tire tread/belt has been reported for the 2000 GMC C2500. The most recently reported issues are listed below.
Firestone steel tex (dot vn11 b1c) tire original equipment, 35000 miles mounted on a GMC, 2500, hd 2000. Left rear tire had a tread separation while consumer was driving at 65 mph. Whole tread sidewall was missing. There was no damage to vehicle.