One problem related to automatic transmission has been reported for the 2003 GMC C2500. The most recently reported issues are listed below.
Vehicle transmission not shifting correctly causing vehicle to accelerate too slowly when pulling out onto highway and not properly downshifting.
| Transfer Case problems | |
| Driveshaft problems | |
| Axle Assembly problems | |
| Automatic Transmission problems | |
| Universal Joint problems | |
| Power Train problems | |
| Differential Unit problems |