One problem related to fuel hoses lines/piping and fittings has been reported for the 2003 GMC C2500. The most recently reported issues are listed below.
The contact owns a 2003 GMC sierra 2500 hd. While driving 35 mph, the warning lights on the instrument panel continued to flash on and off. In addition, the windshield wipers activated and smoke was noticed underneath the hood. The contact had been driving for several minutes before noticing the smoke. The hood could not be opened and the fire department was called. A police report was filed. Ten minutes later, the vehicle was engulfed in flames and destroyed. The failure and current mileages were 65,000. Updated 09/25/08 the consumer stated it was a possible fuel line failure. Updated 09/26/08.