One problem related to tire bubble has been reported for the 2006 Honda Odyssey. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2006 Honda Odyssey based on all problems reported for the 2006 Odyssey.
Horrible, horrible, horrible! I had done a lot of research on what type of used Mini van was the best on the market. Honda kept popping up, so I went and purchased a 2006 Honda Odyssey touring. I loved it until I got a flat tire. I took it to discount tire store (the same place we took our Toyota). That is where we informed that we have the pax tire system. From there it's been a disaster! I've called michelin and the Honda dealership, nobody will do anything to make this situation right! it should be disclosed to buyers before they purchase a car with this tire system on it. The tires cost 300$ a piece and I was informed by michelin that they only last up to 36k miles. The tires that I have right now, still should have 50% of their life, however my rear tire now has a "bubble" on it. It is not safe to drive! shame on Honda and michelin for not doing the right thing! I will never purchase another Honda or michelin tire!.