One problem related to air conditioner has been reported for the 2010 Honda Odyssey. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2010 Honda Odyssey based on all problems reported for the 2010 Odyssey.
(1) air conditioning failed,(2) excessive oil consumption (3) poor mileage (extremely rough running. All occur when the vehicle is operating (in motion).