One problem related to o2 sensor has been reported for the 2018 Honda Odyssey. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2018 Honda Odyssey based on all problems reported for the 2018 Odyssey.
New 2018 Honda Odyssey elite (10-speed transmission) driving on highway and many error messages appeared about steering system, brake system, lane departure system and other failures. Car started having problems downshifting. High rpms for speeds where it should be lower. Sent to dealer for 1 week. Dealer replaced powertrain command module and O2 sensor. Messages disappeared. 1 week after that, transmission started having problems downshifting again while driving on highway. Parked van and center console screen went black then had broken lines of pixels in one or two places.