One problem related to engine has been reported for the 2003 Honda S2000. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2003 Honda S2000 based on all problems reported for the 2003 S2000.
Engine began knocking while driving normally. 14741 miles on car. Oil level was full and had ~1600 miles on oil and filter change. Had vehicle towed to dealer. Warranty denied by Honda. Engine replaced at my expense.