One problem related to engine has been reported for the 2006 Lexus ES330. The most recently reported issues are listed below.
On 9/27/2007, my car (Lexus Es330) went out of control due to sudden acceleration in a parking lot of a shopping center in glenview, IL, and crashed with cars parked nearby. This car incident was reported to the car dealer, but I was told there was no problem with the car. The cost of repair was very high.