One problem related to windshield has been reported for the 2006 Lexus IS250. The most recently reported issues are listed below.
The material used on dash board has softened from normal sun exposure and formed shiny top layer that causes a glare in the windshield when the sun hits it. This has obscured vision of oncoming traffic.
| Wiper problems | |
| Interior Rearview Mirror problems | |
| Windshield problems |