One problem related to manifold/header/muffler/tail pipe has been reported for the 2007 Lexus IS250. The most recently reported issues are listed below.
The contact owns a 2007 Lexus is 250. The contact stated that the vsc and check engine indicators illuminated intermittently. While driving 20 mph, the traction control failed and the vehicle spun out of control onto an open field. The dealer stated that the exhaust pipe was excessively corroded and needed to be replaced. The vehicle was repaired and the manufacturer was notified. The failure mileage was 70,000.