One problem related to seat belt has been reported for the 2006 Lexus IS350. The most recently reported issues are listed below.
Wiring harness defect renders srs/seatbelt pretension system inoperable. Lexus refuses to replace wiring harness without charging $3,000. The issue is listed under a TSB by Lexus and was known to them.
| Front Seat Belt Retractor problems | |
| Seat Belt problems |