One problem related to emission control has been reported for the 1999 Lexus RX300. The most recently reported issues are listed below.
I have a Lexus Rx300 awd and just found out that the transmission needs to be replaced at 120,000 miles. I was very shocked when I took my vehicle in for scheduled maintenance and was told that the transmission is going out and it would be $5720 to repair it. I am very disgusted with this because I started researching the issue and have found that there are several problems with this "so called luxury vehicle" that is suppose to last you to 250,000 miles or more.