Two problems related to engine failure have been reported for the 2001 Lexus RX300. The most recently reported issues are listed below.
Oil sludge cause engine failure in Lexus Rx300. Need to replace short block, overhead gasket set, valve covers,heads and cams for an estimated value of $14k. Car only has 95k miles on it and I changed the oil every 4-5k miles by a Toyota/Lexus auto-mechanic.
Oil sludge in 3. 0l engine causing engine failure.