One problem related to noises during shifting has been reported for the 2005 Lexus RX330. The most recently reported issues are listed below.
The contact owns a 2005 Lexus Rx330. While driving approximately 65 mph, the contact heard a loud noise near the rear of the vehicle. The contact attempted to merge to the emergency lane, but the vehicle independently accelerated and headed back into traffic. Only the front two wheels were operating normally and the rear tires were locked. The gear was shifted into neutral, but the vehicle would not move. The vehicle was towed to the contact's residence and was not diagnosed or repaired. The manufacturer was not notified of the failure. The vehicle was included in NHTSA campaign numbers: 11v112000 (vehicle speed control) and 10v499000 (service brakes, hydraulic). The approximate failure mileage was 131,000.