One problem related to engine has been reported for the 2006 Lexus RX330. The most recently reported issues are listed below.
The contact owns a 2006 Lexus Rx330. While driving at an unknown speed, the contact heard a noise from the engine and the oil indicator illuminated. She stopped the vehicle and had it towed to the dealer for repair. The dealer stated that sludge destroyed her engine. The failure mileage was 94,000.