Two problems related to engine failure have been reported for the 2007 Lexus RX350. The most recently reported issues are listed below.
I was driving on a country road and noticed a/c was acting odd, then temp gauge went to bottom of dial. I couldn't stop on this road. I was trying to get to granddaughter's house. I stopped at light and couldn't start it. I called aaa and car was transported to Lexus dealer who tested car and said engine failed. There were 122000 miles when tested at dealer. The car has been dealer serviced the entire time. It was serviced at 120,000 and all systems ok. I've had an 80 datsun that lasted 250,000 miles. The dealer said that used engine $8500. I expected much better from Lexus. Reading some NHTSA reports there seem to be a rash of oil lines failing. There was no water hose problem according to dealer checking it.
I purchased my Lexus RX 350 Dec 2006. I have 35, 500 miles on my car. My car is used for personal usage. My transmission was recently replaced March 2009. Now I recently had engine failure one month after transmission failure. To make matters worse, I was informed that my transmission is leaking. This problem was discovered after engine failure and replacement transmission.