One problem related to transmission failure has been reported for the 2008 Lexus RX350. The most recently reported issues are listed below.
The transmission completely failed while I was driving on the freeway. This was very dangerous and caused a safety hazard. The transmission had to be replaced. The power steering rack had to also be replaced. It's ridiculous that these failures occurred before 120,000 miles.
| Power Train problems | |
| Transmission Failure problems | |
| Automatic Transmission Cooler problems | |
| Transmission Noise problems |