One problem related to engine burning oil has been reported for the 2010 Lexus RX350. The most recently reported issues are listed below.
My wife was coming from work in the early morning on April 1, 2019 at highway speed around 70 to 75mph. All of a sudden she could hear big noise coming out of engine, warning lights started coming on the dash and she could mange to stop the car in the emergence lane. She could smell the oil burning from the front. The vehicle was towed to the auto shop and was evaluated next week. They told me that engine have big holes in the front, rear and at the bottom. Transfer case also got a big hole along with the battery. The vehicle has had a regular oil change and routing inspection in all the previous years. I have shown this to couple of repair shops and they told me that they have never seen this kind of instance in any vehicle and especially Lexus.