One problem related to door latch has been reported for the 2005 Mazda MPV. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2005 Mazda MPV based on all problems reported for the 2005 MPV.
The driver's side power sliding door rarely works. Typically it opens 1-3 inches then stops and beeps. If I manually open it a few more inches then press the button again it works on occasion, other times I must turn off the power to move it at all. It is a 2005 Mpv with only 22,500 miles. Also, on occasion the rear latch of the sliding door cycles, like it's trying to secure the door, while driving. I only recently purchased it so I don't know if this only occurs in winter (in WI) or not. I have not yet taken it to the dealer. However, my next door neighbor has the identical van (except his has 35,000 miles and is an lx, rather than my ES). He has had his for two years and has problems with both power doors, especially in winter. His has been to the dealer three times with them claiming the can not correct the problem. He has problems many times even opening the doors manually (with power option off) in winter. Both of us have three kids and this is tremendously irritating needing to load three children through the front doors, climb over the driver's buckets to the rear and buckle the kid's in, climb back over the buckets and drop them off at school repeating the whole process. Other than the "sliding" doors we love our vans.