45 problems have been reported for the 1999 Mercedes Benz C280. The following chart shows the 15 most common problems for 1999 Mercedes Benz C280. The number one most common problem is related to the vehicle's engine and engine cooling with 11 problems. The second most common problem is related to the vehicle's suspension (6 problems).
The following chart shows the number of problems reported during each of the service years since the debut of the 1999 Mercedes Benz C280 in 1999.
| Service Year | Number of Problems |
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| 1999 |
When making the decision between buying a new or used Mercedes Benz C280, the following table can be used to compare the 1999 Mercedes Benz C280 with the Mercedes Benz C280 from other model years. Note that the number of problems reported for the 1999 C280 is 45 while the average number of problems reported for the 7 model years of the Mercedes Benz C280 is 24.