23 problems have been reported for the 2004 Mercedes Benz C320. The following chart shows the 15 most common problems for 2004 Mercedes Benz C320. The number one most common problem is related to the vehicle's fuel system, other with 4 problems. The second most common problem is related to the vehicle's equipment (3 problems).
The following chart shows the number of problems reported during each of the service years since the debut of the 2004 Mercedes Benz C320 in 2004.
| Service Year | Number of Problems |
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| 2022 | |
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| 2004 |
When making the decision between buying a new or used Mercedes Benz C320, the following table can be used to compare the 2004 Mercedes Benz C320 with the Mercedes Benz C320 from other model years. Note that the number of problems reported for the 2004 C320 is 23 while the average number of problems reported for the 7 model years of the Mercedes Benz C320 is 41.