Two problems related to power train have been reported for the 1999 Mercedes Benz E320. The most recently reported issues are listed below.
Engine just stops running/stalling after from 15 - 30 minutes of driving. Has happened twice midway through left turns. (scary!) can happen anytime and any speed.
Consumer 1999 E320 had transmission problems and caught on fire with 110,000 miles on it. The consumer stated the transmission problems started when the vehicle only had 55,000 miles. Before the fire, the vehicle had a tire leak and a defective lamp assembly.