One problem related to engine has been reported for the 2004 Mercedes Benz E320. The most recently reported issues are listed below.
I was driving a 2004 mb e-320 on the road, suddenly the lights on the dashboard were all lit up and then I lost power to the car. I made my way to the curb along industrial blvd near west sacramento. The car was towed to the mb sacramento dealership. A quick scan found a fault code. It was the crank position sensor malfunction. The dealership has to replace the sensor.