One problem related to adaptive cruise control has been reported for the 2012 Mercedes Benz E350. The most recently reported issues are listed below.
1. Backup camera will periodically display a blank screen when shifted into reverse. System has to be shutdown and restarted to get the camera to work again. Tends to happen on rainy days when camera most needed. No accident has occurred as a result to date. Date of last occurrence is an approximation. 2. Distronic plus system (adaptive cruise) will disengage unexpectedly when coming to a stop in traffic or if in stop and go traffic. The system beeps once and a red light flashes, but this is easily missed if radio is playing or driver is distracted. This has almost caused several roll forward rear-end collisions, prevented only by quick driver intervention. Neither issue has been addressed with the dealer since the vehicle is out of warranty.