One problem related to headlights has been reported for the 2013 Mercedes Benz E350. The most recently reported issues are listed below.
The blind spot assist (bsa) system is malfunctioning and causes intermittent problems to the headlights malfunctioning during driving or dashboard messages flashing while driving. This problem is widely reported on mercedes E350 4matic cars across multi year models. Mercedes is unwilling to share data of this systemic failures. This should be a recall for defective bsa system components.