One problem related to tire tread/belt has been reported for the 2016 Mercedes Benz E350. The most recently reported issues are listed below.
Tires have under 7000 miles. Traveling on i75 in florida the car started to vibrate. I slowed down and was able to make it to a mercedes dealership. The mechanic informed me that the cords in both rear tires had separated. I had the tires replaced which were not under any warrantee. I have the same tires on the front of the vehicle which I am very concerned about as the mechanic told me I was lucky the tires didn't explode. 245/40r18.